Women’s Health Bulletin

Published by: Kowsar

Correlation Between Hormonal and Neurochemical Changes and Depression With Menopausal STATUS: A Systematic Review

Mostafa Chashmposh 1 , Saeed Shirali 2 , * , Esmaeel Ebrahimi 1 and Alireza Barari 3
Authors Information
1 Department of Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University of Ayatollah Amoli, Amol, IR Iran
Article information
  • Women's Health Bulletin: July 25, 2015, 2 (3); e25037
  • Published Online: July 18, 2015
  • Article Type: Review Article
  • Received: October 31, 2014
  • Accepted: April 20, 2015
  • DOI: 10.17795/whb-25037

To Cite: Chashmposh M, Shirali S, Ebrahimi E, Barari A. Correlation Between Hormonal and Neurochemical Changes and Depression With Menopausal STATUS: A Systematic Review, Women Health Bull. 2015 ; 2(3):e25037. doi: 10.17795/whb-25037.

Copyright © 2015, Health Policy Research Center, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Objectives
3. Data Sources
4. Study Selection
5. Data Extraction
6. Results
7. Conclusions
  • 1. Prelevic GM, Jacobs HS. Menopause and post-menopause. Baillieres Clin Endocrinol Metab. 1997; 11(2): 311-40[PubMed]
  • 2. Greendale GA, Lee NP, Arriola ER. The menopause. Lancet. 1999; 353(9152): 571-80[DOI][PubMed]
  • 3. Al-Azzawi F, Palacios S. Hormonal changes during menopause. Maturitas. 2009; 63(2): 135-7[DOI][PubMed]
  • 4. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging. Climacteric. 2012; 15(2): 105-14[DOI][PubMed]
  • 5. Rohr UD. The impact of testosterone imbalance on depression and women's health. Maturitas. 2002; 41 Suppl 1-46[PubMed]
  • 6. Noble RE. Depression in women. Metabolism. 2005; 54(5 Suppl 1): 49-52[DOI][PubMed]
  • 7. Birkhauser M. Depression, menopause and estrogens: is there a correlation? Maturitas. 2002; 41 Suppl 1-8[PubMed]
  • 8. Cohen LS, Soares CN, Vitonis AF, Otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles. Arch Gen Psychiatry. 2006; 63(4): 385-90[DOI][PubMed]
  • 9. Farzanegi P, Ayatollahi P, Barari AR, Fakori Joybari M, Shirali S, Shojaee M, et al. Effect of Eight-Week Consumption of Purslane Extract on Peroxidane/Antioxidant Balance in Women with Type 2 Diabetes. Med Laboratory J. 2014; 8(2): 1-7
  • 10. Chashmpoosh M, Shirali S, Javidnia J. Menopause and Depression. The 3rd Iranian International Conference on Women,s Health. 2014;
  • 11. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. 2009; 5
  • 12. Rajewska J, Rybakowski JK. Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(4): 705-9[DOI][PubMed]
  • 13. Okatani Y, Sagara Y. Amplification of nocturnal melatonin secretion in women with functional secondary amenorrhoea: relation to endogenous oestrogen concentration. Clin Endocrinol (Oxf). 1994; 41(6): 763-70[PubMed]
  • 14. Okatani Y, Morioka N, Hayashi K. Changes in nocturnal pineal melatonin synthesis during the perimenopausal period: relation to estrogen levels in female rats. J Pineal Res. 1999; 27(2): 65-72[PubMed]
  • 15. Woods NF, Mitchell ES, Smith-Dijulio K. Cortisol levels during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study. Menopause. 2009; 16(4): 708-18[DOI][PubMed]
  • 16. Woods NF, Carr MC, Tao EY, Taylor HJ, Mitchell ES. Increased urinary cortisol levels during the menopausal transition. Menopause. 2006; 13(2): 212-21[DOI][PubMed]
  • 17. Gonzales GF, Carrillo C. Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels. Maturitas. 1993; 17(1): 23-9[PubMed]
  • 18. Sohrabji F, Miranda RC, Toran-Allerand CD. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci U S A. 1995; 92(24): 11110-4[PubMed]
  • 19. Campbell S, Whitehead M. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynaecol. 1977; 4(1): 31-47[PubMed]
  • 20. Schneider MA, Brotherton PL, Hailes J. The effect of exogenous oestrogens on depression in menopausal women. Med J Aust. 1977; 2(5): 162-3[PubMed]
  • 21. Schmidt PJ, Nieman L, Danaceau MA, Tobin MB, Roca CA, Murphy JH, et al. Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Obstet Gynecol. 2000; 183(2): 414-20[DOI][PubMed]
  • 22. Pearlstein T, Rosen K, Stone AB. Mood disorders and menopause. Endocrinol Metab Clin North Am. 1997; 26(2): 279-94[PubMed]
  • 23. Huerta R, Mena A, Malacara JM, Diaz de Leon J. Symptoms at perimenopausal period: its association with attitudes toward sexuality, life-style, family function, and FSH levels. Psychoneuroendocrinology. 1995; 20(2): 135-48[PubMed]
  • 24. Yazici KM, Akinci A, Sutcu A, Ozcakar L. Bone mineral density in premenopausal women with major depressive disorder. Psychiatry Res. 2003; 117(3): 271-5[PubMed]
  • 25. Okatani Y, Morioka N, Wakatsuki A. Changes in nocturnal melatonin secretion in perimenopausal women: correlation with endogenous estrogen concentrations. J Pineal Res. 2000; 28(2): 111-8[PubMed]
  • 26. Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev. 1991; 12(2): 151-80[DOI][PubMed]
  • 27. Luttge WG, Wallis CJ. In vitro accumulation and saturation of 3H-progestins in selected brain regions and in the adenohypophysis, uterus and pineal of the female rat. Steroids. 1973; 22(4): 493-502[PubMed]
  • 28. Cardinali DP, Nagle CA, Rosner JM. Effects of estradiol on melatonin and protein synthesis in the rat pineal organ. Horm Res. 1974; 5(5): 304-10[PubMed]
  • 29. Houssay AB, Barcelo AC. Effects of estrogens and progesterone upon the biosynthesis of melatonin by the pineal gland. Experientia. 1972; 28(4): 478-9[PubMed]
  • 30. Cardinali DP, Vacas MI, Ritta MN. A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures. Experientia. 1981; 37(2): 203-4[PubMed]
  • 31. Berga SL, Mortola JF, Yen SS. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 1988; 66(1): 242-4[DOI][PubMed]
  • 32. Brzezinski A, Lynch HJ, Seibel MM, Deng MH, Nader TM, Wurtman RJ. The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women. J Clin Endocrinol Metab. 1988; 66(5): 891-5[DOI][PubMed]
  • 33. Bartsch C, Seeger H, Muck AO, Lippert TH. The effect of estradiol on the production of melatonin in postmenopausal women. Int J Clin Pharmacol Ther. 1995; 33(7): 401-3[PubMed]
  • 34. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007; 87(3): 873-904[DOI][PubMed]
  • 35. Yen SS, Laughlin GA. Aging and the adrenal cortex. Exp Gerontol. 1998; 33(7-8): 897-910[PubMed]
  • 36. Laughlin GA, Barrett-Connor E. Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2000; 85(10): 3561-8[DOI][PubMed]
  • 37. Vamvakopoulos NC, Chrousos GP. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction. J Clin Invest. 1993; 92(4): 1896-902[DOI][PubMed]
  • 38. Mattsson C, Olsson T. Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem. 2007; 14(27): 2918-24[PubMed]
  • 39. The neurobiology of stress: understanding regulation of affect during female biological transitions. Seminars in reproductive endocrinology. : 19-35
  • 40. Greendale GA, Unger JB, Rowe JW, Seeman TE. The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur studies-Mac. J Am Geriatr Soc. 1999; 47(7): 799-803[PubMed]
  • 41. Worthman CM. Endocrine pathways in differential well-being across the life course. Kuh and Hardy. 2002; : 197-232[DOI]
  • 42. Meneses A. 5-HT system and cognition. Neurosci Biobehav Rev. 1999; 23(8): 1111-25[PubMed]
  • 43. Joffe H, Cohen LS. Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol Psychiatry. 1998; 44(9): 798-811[PubMed]
  • 44. Guicheney P, Leger D, Barrat J, Trevoux R, De Lignieres B, Roques P, et al. Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms. Eur J Clin Invest. 1988; 18(3): 297-304[PubMed]
  • 45. Berendsen HH. The role of serotonin in hot flushes. Maturitas. 2000; 36(3): 155-64[PubMed]
  • 46. Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry. 1998; 44(9): 839-50[PubMed]
  • 47. Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL, et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature. 1997; 389(6653): 856-60[DOI][PubMed]
  • 48. Hefti F, Knusel B, Lapchak PA. Chapter 31: Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. Progress in brain research. 1993; 98: 257-63[DOI]
  • 49. Lindsay RM. Neurotrophic growth factors and neurodegenerative diseases: therapeutic potential of the neurotrophins and ciliary neurotrophic factor. Neurobiol Aging. 1994; 15(2): 249-51[PubMed]
  • 50. Begliuomini S, Casarosa E, Pluchino N, Lenzi E, Centofanti M, Freschi L, et al. Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod. 2007; 22(4): 995-1002[DOI][PubMed]
  • 51. Tapia-Arancibia L, Rage F, Givalois L, Arancibia S. Physiology of BDNF: focus on hypothalamic function. Front Neuroendocrinol. 2004; 25(2): 77-107[DOI][PubMed]
  • 52. Scharfman HE, MacLusky NJ. Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS. Front Neuroendocrinol. 2006; 27(4): 415-35[DOI][PubMed]
  • 53. Kimmick GG, Lovato J, McQuellon R, Robinson E, Muss HB. Randomized, double-blind, placebo-controlled, crossover study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen. Breast J. 2006; 12(2): 114-22[DOI][PubMed]
  • 54. Loprinzi CL, Sloan JA, Perez EA, Quella SK, Stella PJ, Mailliard JA, et al. Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol. 2002; 20(6): 1578-83[PubMed]
  • 55. Puri BK. Nutrients, Stress, and Medical Disorders. 2005; : 221-30
  • 56. Kannel WB, Hjortland MC, McNamara PM, Gordon T. Menopause and risk of cardiovascular disease: the Framingham study. Ann Intern Med. 1976; 85(4): 447-52[PubMed]
  • 57. Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis. 1993; 98(1): 83-90[PubMed]
  • 58. Ushiroyama T, Okamoto Y, Sugimoto O. Plasma lipid and lipoprotein levels in perimenopausal women. Clinical research in 1198 Japanese women. Acta Obstet Gynecol Scand. 1993; 72(6): 428-33[PubMed]
  • 59. Cho EJ, Min YJ, Oh MS, Kwon JE, Kim JE, Lee WS, et al. Effects of the transition from premenopause to postmenopause on lipids and lipoproteins: quantification and related parameters. Korean J Intern Med. 2011; 26(1): 47-53[DOI][PubMed]
  • 60. Manfredini R, Caracciolo S, Salmi R, Boari B, Tomelli A, Gallerani M. The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link. J Int Med Res. 2000; 28(6): 247-57[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments