Women’s Health Bulletin

Published by: Kowsar

The Effect of Amniotic Membrane on the Healing of Cesarean Wounds: A Randomized Clinical Trial

Zahra Molazem 1 , Fatemeh Mohseni 2 , Mahnaz Rakhshan 3 , * , Sareh Keshavarzi 4 and Masoumeh Younesi 5
Authors Information
1 Community Based Nursing and Midwifery Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Student at Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Medical-Surgical Nursing Department, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Depatment of Bio Statistics, Shiraz University of Medical Sciences, Shiraz, IR Iran
5 Gerash Amir-al-Momenin Medical and Educational Center, Gerash, Fars, IR Iran
Article information
  • Women’s Health Bulletin: April 2018, 5 (2); e13109
  • Published Online: March 10, 2018
  • Article Type: Research Article
  • Received: April 16, 2017
  • Revised: June 20, 2017
  • Accepted: August 16, 2017
  • DOI: 10.5812/whb.13109

How to Cite: Molazem Z, Mohseni F, Rakhshan M, Keshavarzi S, Younesi M. The Effect of Amniotic Membrane on the Healing of Cesarean Wounds: A Randomized Clinical Trial, Women Health Bull. 2018 ; 5(2):e13109. doi: 10.5812/whb.13109.

Copyright © 2018, Women’s Health Bulletin. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Moore B. Appropriate technology for birth. Lancet. 1985;326(8458):787.
  • 2. Danforth DN, Gibbs RS. Danforth's obstetrics and gynecology. Lippincott Williams and Wilkins; 2008.
  • 3. Azami-Aghdash S, Ghojazadeh M, Dehdilani N, Mohammadi M, Asl Amin Abad R. Prevalence and Causes of Cesarean Section in Iran: Systematic Review and Meta-Analysis. Iran J Public Health. 2014;43(5):545-55. [PubMed: 26060756].
  • 4. Samadi S, Khadivzadeh T, Emami A, Moosavi NS, Tafaghodi M, Behnam HR. The effect of Hypericum perforatum on the wound healing and scar of cesarean. J Altern Complement Med. 2010;16(1):113-7. doi: 10.1089/acm.2009.0317. [PubMed: 20064022].
  • 5. Sarsam SE, Elliott JP, Lam GK. Management of wound complications from cesarean delivery. Obstet Gynecol Surv. 2005;60(7):462-73. [PubMed: 15995563].
  • 6. Dahifar H. Early weight loss of breast-fed neonates born under C-section in their first 48 hours of life. Para Med Sci. 2003;1(4):203-10.
  • 7. Mohammadi AA, Johari HG, Eskandari S. Effect of amniotic membrane on graft take in extremity burns. Burns. 2013;39(6):1137-41. doi: 10.1016/j.burns.2013.01.017. [PubMed: 23523222].
  • 8. Yeh LK, Chen WL, Li W, Espana EM, Ouyang J, Kawakita T, et al. Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2005;46(2):479-86. doi: 10.1167/iovs.04-1014. [PubMed: 15671272].
  • 9. Zelen CM, Serena TE, Denoziere G, Fetterolf DE. A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers. Int Wound J. 2013;10(5):502-7. doi: 10.1111/iwj.12097. [PubMed: 23742102].
  • 10. Cornwell KG, Landsman A, James KS. Extracellular matrix biomaterials for soft tissue repair. Clin Podiatr Med Surg. 2009;26(4):507-23. doi: 10.1016/j.cpm.2009.08.001. [PubMed: 19778685].
  • 11. Kim JS, Kim JC, Na BK, Jeong JM, Song CY. Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res. 2000;70(3):329-37. doi: 10.1006/exer.1999.0794. [PubMed: 10712819].
  • 12. Niknejad H, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian AM. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
  • 13. Hao Y, Ma DH, Hwang DG, Kim WS, Zhang F. Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. 2000;19(3):348-52. [PubMed: 10832697].
  • 14. Lee SB, Li DQ, Tan DT, Meller D, Tseng SC. Suppression of TGF-ß signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane. Curr Eye Res. 2000;20(4):325-34.
  • 15. Sangwan VS, Basu S. Antimicrobial properties of amniotic membrane. Br J Ophthalmol. 2011;95(1):1-2. doi: 10.1136/bjo.2010.184259. [PubMed: 21163818].
  • 16. King AE, Paltoo A, Kelly RW, Sallenave JM, Bocking AD, Challis JR. Expression of natural antimicrobials by human placenta and fetal membranes. Placenta. 2007;28(2-3):161-9. doi: 10.1016/j.placenta.2006.01.006. [PubMed: 16513165].
  • 17. Adly OA, Moghazy AM, Abbas AH, Ellabban AM, Ali OS, Mohamed BA. Assessment of amniotic and polyurethane membrane dressings in the treatment of burns. Burns. 2010;36(5):703-10. doi: 10.1016/j.burns.2009.09.003. [PubMed: 20004061].
  • 18. Mermet I, Pottier N, Sainthillier JM, Malugani C, Cairey-Remonnay S, Maddens S, et al. Use of amniotic membrane transplantation in the treatment of venous leg ulcers. Wound Repair Regen. 2007;15(4):459-64. doi: 10.1111/j.1524-475X.2007.00252.x. [PubMed: 17650088].
  • 19. Parolini O, Solomon A, Evangelista M, Soncini M. Human term placenta as a therapeutic agent: from the first clinical applications to future perspectives. Human placenta: structure and development. Nova Sci Pub. 2010:1-48.
  • 20. Mamede AC, Botelho MF. Amniotic Membrane: Origin, Characterization and Medical Applications. Springer; 2015.
  • 21. Heidari T, Roozbahani N, Farahani LA, Attarha M, Torkestani NA, Jamilian M. Does Iranian Astragalus gossypinus honey assist in healing caesarean wounds and scars?. EuJIM. 2013;5(3):226-33.
  • 22. Razmjoo N, Adeli M, Tara F, Ebrahimzadeh S. The effect of early post cesarean feeding on wound healing. IJN. 2012;3:15-6.
  • 23. Hill PD. Psychometric properties of the REEDA. J Nurs Midwif. 1990;35(3):162-5.
  • 24. Razmjoo N, Adeli M, Tara F, Ebrahimzadeh S. Effect of Early Oost Cesarean Feeding on Wound Healing. Horizon Med Sci. 2013;19(3):83-8.
  • 25. Alsina-Gibert M, Pedregosa-Fauste S. Amniotic membrane transplantation in the treatment of chronic lower limb ulcers. Actas Dermosifiliogr. 2012;103(7):608-13. doi: 10.1016/j.ad.2012.01.010. [PubMed: 22578292].
  • 26. Schmidt W. The amniotic fluid compartment: the fetal habitat. Advanc Anatom Embryol Cell Biol. 1991;127:1-100.
  • 27. Nordback PH, Miettinen S, Kaariainen M, Pelto-Huikko M, Kuokkanen H, Suuronen R. Amniotic membrane reduces wound size in early stages of the healing process. J Wound Care. 2012;21(4):190-196-7. doi: 10.12968/jowc.2012.21.4.190. [PubMed: 22584678].

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